Operation High Impact F5 starts at midnight tonight, Friday August 9, with SA Police targeting the Fatal 5 offences - drink and drug driving, speeding, distraction, seatbelts and dangerous road users.
The campaign will continue for four weeks, concluding on Thursday, September 5.
SAPOL Commissioner Grant Stevens said South Australian drivers needed to take responsibility for their driving behaviour.
"We need to change driver and road user behaviour," he said.
"With 73 people killed so far on our roads this year - that is 30 more people who have been killed on our roads compared to 43 at the same time last year.
"That is an additional 30 families who are suffering as a result of these deaths.
"That is 30 more incidents that emergency responders have had to attend and advise families of these deaths. This is simply unacceptable."
Commissioner Stevens said drivers who took unnecessary risks or made bad decisions could cause heartbreaking conequences.
"Put bluntly - not wearing a seat belt - KILLS; speeding - KILLS; distraction - like using a mobile telephone whilst driving - KILLS; choosing to drink or drug drive - KILLS; and driving dangerously or like an idiot - KILLS," he said.
"We simply cannot keep going the way we have.
Further information on the Fatal Five can be found on the Police website:https://www.police.sa.gov.au/__data/assets/pdf_file/0005/786785/Fatal-Five-fact-sheet-2019.pdf