Over the next 20 years there could be as many as 124 deaths and 1180 injuries on the Augusta and Dukes highways, if the Federal government does not invest in upgrades, according to the RAA.
The organisation has based its calculations on current crash rates across the two major roads.
The RAA wants the Federal government to duplicate both highways, which is estimated at $2 billion for each project.
Also on the wishlist is the completion of Adelaide's North-South Corridor, at around $2.9 billion and the separation of five major road and interstate rail level crossings around the city's suburbs at around $200 million.
The other request was to formally recognised the Riddoch Highway in the National Highway Network.
RAA general manager public policy Jayne Flaherty said long-term investment was needed to deliver social and economic benefits to all South Australians.
"SA motorists already pay almost $1 billion a year in federal excise and GST on fuel, so it's only fair that whoever wins the next federal election commits to funding road transport projects for South Australia,'' Ms Flaherty said.
"With safety top of mind, we also need the next government to act strategically and provide national leadership on a framework for developing and trialling autonomous vehicles.
"The time to take action is now.
"RAA wants to see the government include this much needed funding in its upcoming budget, and these crucial commitments in the opposition's budget reply.''
The RAA wants voters to show their support and join its campaign on transport priorities.
For information on how to show support visit: https://samotor.raa.com.au/fedelection19/